In the animal groups (WT, TNFR2+/−, TNFR2−/− mice) daily pre-treated with 0.5 mg/kg of LPS for 7 days before intracerebral implantation of C6 glioma cells, the averaged mortality rate at 14 dpi from these animal groups was about 80%. Here, TNFRSF1B is linked to central nervous system cancer.