MAPT and tauopathy: Immunohistochemistry analyses of phosphorylated Tau revealed six distinct astroglial phenotypes associated with tauopathies including astrocytic plaques (AP), tufted astrocytes (TA), ramified astrocytes (RA), and globular astroglial inclusions (GAI) in primary tauopathies, and thorn shaped astrocytes (TSA) and granular/fuzzy astrocytes (GFA) in aging-related Tau astrogliopathy (ARTAG) [12,13,14,15].