PSEN1 and Alzheimer disease: The role of FMT in AD has been recently investigated in APPswe/PS1dE9 transgenic mouse and in a novel animal model of AD, the ADLPAPT mice characterized by three human transgenes, including amyloid precursor protein, presenilin-1, and tau which shows amyloid plaques, neurofibrillary tangles and reactive gliosis [145,146,147].