Our results indicate that genetic variants involved in pathways governing host immunity, such as innate and adaptive immune system, interferon (IFN) signalling, interleukin (IL) signalling, antigen processing by major histocompatibility complex (MHC) and cytokine signalling, showed significant variation between asymptomatic and severe COVID-19 patients (Table S1). This evidence concerns the gene IFNA1 and COVID-19.