In light of the study of Ota et al. [9], who investigated Notch1, 2, and 3 on mRNA and protein levels and observed their decreased expressions in the psoriatic epidermis compared with normal epidermis, our study results may be supportive of a role of the NOTCH3 (6746T>C) polymorphism in the pathogenesis of psoriasis. Here, NOTCH3 is linked to psoriasis.