Moreover, since in our literature search we did not come across information about a possible genetic interplay between the SNPs of NOTCH3 (6746T>C) and PSMA6 (-8C>G) in psoriasis, the aim of this study was to analyze the NOTCH3 (6746T>C) and PSMA6 (-8C>G) polymorphisms and the role they play in genetic susceptibility to psoriasis in Polish psoriatic patients. This evidence concerns the gene PSMA6 and psoriasis.