In addition, the in silico analysis allowed predicting a variety of transcription factors that have the potential to co-regulate the pancreatic expression of EDEM2, MYH7B, MAP1LC3A, and CPNE1 genes, and these TFs represent the pathways playing a key role in the development of type 2 diabetes such as TGF-beta signaling, notch signaling, Wnt Signaling, TP53 signaling, cell cycle, apoptosis, autophagy, SUMOylation, insulin resistance and energy metabolism (Figure 4). Here, INS is linked to type 2 diabetes mellitus.