GDF5 and type 2 diabetes mellitus: Interestingly, genes such as GDF5, CEP250, ERGIC3, FER1L4, SPAG4, CPNE1, and RBM12 at 20q11.22 were enriched with a term BMI-adjusted waist-to-hip ratio (GWAS catalog), a trait which is known to be associated with diabetes risk [136] as well as polymorphisms rs143384 and rs224333 of the GDF5 gene, as established by genome-wide association studies performed on type 2 diabetes [137,138].