HPGDS and type 2 diabetes mellitus: As it has been observed by the present study, our previous [31,32,34,35] and some other [36,37,38] studies, the genetic factors contribute to both the levels of glutathione and susceptibility to type 2 diabetes, and single nucleotide polymorphisms at genes encoding enzymes for glutathione metabolism such as glutamate cysteine ligase (catalytic and modifier subunits), gamma-glutamyl cyclotransferase, glutathione S-transferases (mu, pi, and theta classes), gamma-glutamyltransferase 6 and 7 are illustrative examples of that relationship.