NSD2, also called Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) or Multiple Myeloma SET domain protein (MMSET) is located on the short arm of chromosome 4 (4p16.3), a locus targeted by a recurrent t(4;14)(p16;q32) translocation found in up to 20% of patients with multiple myeloma. This evidence concerns the gene NSD2 and plasma cell myeloma.