When fused to the N-terminus of NUP98, the NSD1-SET gains transforming activities in hematopoietic cells, resulting in myelodysplasia and AML, and the presence of a NUP98-NSD1 (and other NUP98-fusions) is often associated with primary resistance to chemotherapy [86,87]. The gene discussed is NSD1; the disease is acute myeloid leukemia.