NSD3 was mapped to the short arm of chromosome 8 (8p11.2), a locus involved in cancer-associated amplifications and translocations, such as t(8;11)(p11;p15) associated with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) [12]. The gene discussed is NSD3; the disease is acute myeloid leukemia.