For instance, Scher et al. [23] analyzed the subgingival colonization of Pg by 16S rRNA pyrosequencing and identified Pg in 55% of patients with new-onset RA (without RA medication, n = 31), in 47% of patients with chronic RA (n = 34), and in 27% of healthy controls (n = 18). This evidence concerns the gene JUP and rheumatoid arthritis.