In the current study, the clear reduction of PPARγ and PPARα expression found in the L-NAME group indicates that the retinal inflammatory profile could be affected in arterial hypertension via PPAR inhibition, an alteration that could be prevented with ACE oil and with EVOO-enriched diets (thus supporting a beneficial anti-inflammatory strategy via PPAR upregulation), with better performance in the case of ACE oil. The gene discussed is PPARA; the disease is Hypertension.