GLA and Fabry disease: Fabry disease (FD), an X-linked lysosomal storage disorder, is characterized by mutations in the GLA gene, encoding the α-galactosidase A enzyme, causing the absence or reduction of the activity of the lysosomal enzyme and a subsequent lysosomal accumulation of globotriaosilceramide (Gb3) and other glycosphingolipids in different cell types, such as cardiomyocytes.