Zaragoza et al. analyzed a Spanish family affected by familial DCM due to BAG3 (BAG cochaperone 3) gene mutations: circulating miR-154-5p, miR-182-5p, miR-1249-ep, miR-3191-3p, miR-6769b-3p, and miR-6855-5p were increased in BAG3+ mutant carriers compared to BAG3 wild-type. The gene discussed is BAG3; the disease is familial dilated cardiomyopathy.