However, during preeclampsia there is a change in the endometrial levels of various angiogenic growth factors, such as vascular endothelial growth factor A (VEGF-A); mRNAs encoding VEGF-C; placental growth factor (PlGF); the angiopoietins, angiopoietin 1(Ang1) and Ang2; and the receptors VEGFR-3 (Flt-4), Tie 1, and Tie 2 [23]. The gene discussed is FLT4; the disease is preeclampsia.