SYN1 and Parkinson disease: Correlation analysis between the change in the gait parameters and gene expression showed that the expression changes in SYN1 (p = 0.0318, r = 0.6761) and ANKRD22 (p = 0.0143, r = 0.7404) were positively correlated with changes in stride length (Figure 4B), thereby suggesting that SYN1 and ANKRD22 are acupuncture therapy response biomarkers in the blood of patients with PD.