Correlation analysis between the change in the gait parameters and gene expression showed that the expression changes in SYN1 (p = 0.0318, r = 0.6761) and ANKRD22 (p = 0.0143, r = 0.7404) were positively correlated with changes in stride length (Figure 4B), thereby suggesting that SYN1 and ANKRD22 are acupuncture therapy response biomarkers in the blood of patients with PD. The gene discussed is ANKRD22; the disease is Parkinson disease.