Our previous research showed that carbonic anhydrate 9 (CA9) polymorphism is associated with a 4.5-fold increased risk of lymph node metastasis while growth arrest-specific 5 (GAS5) SNPs play a protective role in nodal invasion (OR 0.545, p = 0.043) [50,51]. This evidence concerns the gene CA9 and metastatic malignant neoplasm in the lymph nodes.