NPPB and heart failure: While previous studies suggested that miR-133 and miR-423-5p can be used as heart failure biomarkers, Bauters et al. showed that these miRNAs were not associated with LVR echocardiographic parameters (LVEF, LVEDV, and LVESV), brain natriuretic peptide, cTnI, or C reactive protein over one year [99].