Fasting further reduced PBGD activity (p = 0.0001 at ANOVA; adj p = 0.04 vs. siPBGD untreated (NT) and vs. fasted Scramble; Figure S1B) and promoted ALAS1 upregulation without increasing heme content (p = 0.003 at ANOVA; p = 0.03 vs. siPBGD-NT; Figure S1C,D), as occurs in AIP subjects. Here, ALAS1 is linked to autoimmune pancreatitis.