In keeping with these findings, we found that the induction of fasting through glucose deprivation halved PBGD enzymatic activity at 50% and sensitized siPBGD cells to upregulate ALAS1, likely via PGC1α, without increasing heme production, similar to what has been reported in AIP rodents and patients exposed to precipitating factors [10,16]. Here, PPARGC1A is linked to autoimmune pancreatitis.