Furthermore, hepatic transcriptome of AIP mice revealed that the majority of differentially expressed genes during a stress-induced attack were involved in the circadian rhythm, mitochondrial biogenesis, and oxidative phosphorylation (OXPHOS), whose regulation closely depends on peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A, encoding the PGC1-α transcription factor) [12]. The gene discussed is PPARGC1A; the disease is autoimmune pancreatitis.