TNF and ovarian carcinoma: When the serum IL-8 level was 4.09 ng/mL or higher, the sensitivity and specificity of a diagnosis of ovarian carcinoma were 70% and 96%, respectively (p < 0.0001); and when the serum TNF-α concentration was 2.63 ng/mL or higher, the sensitivity and specificity were 85.7% and 79.3% respectively (p < 0.0001) (Table 6).