In addition to the presence of the HLA-B*58:01 allele, one-locus haplotypes of HLA-A*02:01/HLA-A*24:02 and HLA-A*02:01/HLA-A*29:01 probably play an important role in the occurrence of ADRs with mild symptoms in patients with gout treated with ALP. This evidence concerns the gene HLA-B and gout.