Furthermore, previous studies have shown a strong relationship between the presence of HLA-B*58:01 and severe symptoms such as SJS and TEN in patients with ALP-induced SCARs; however, the relationship between HLA-B*58:01 and mild symptoms in patients with gout treated with ALP is unclear [7,8,9,10,11,12,13,14,15,16,17,18]. Here, HLA-B is linked to toxic epidermal necrolysis.