HLA-B and toxic epidermal necrolysis: It is well known that the presence of HLA-B*58:01 is closely related to the occurrence of severe adverse drug reactions (SJS, SJS/TEN, TEN, and DRESS) in the skin of patients (SCARs) when ALP is used for gout treatment, especially for Black and Asian people rather than white people [11,12,13,14,15,16,17,18,19,20,21,22,29].