In conclusion, the results described in this work demonstrate that, unlike other forms of pediatric lymphoma, such as Burkitt lymphoma [16] and anaplastic large cell lymphoma [17] for which MDD represents an independent prognostic factor, MDD seems to play a less relevant prognostic role in T-LBL when compared to the mutational status of NOTCH1/FBXW7. Here, NOTCH1 is linked to Burkitt lymphoma.