Additional features suggestive of a diagnosis of sarcoidosis include a lymphocytosis > 15%, CD4/CD8 ratio > 3.5, CD103 ratio of <0.2 and a transbronchial biopsy demonstrating noncaseating granulomas, whereas a CD4/CD8 ratio < 1 and elevated neutrophil and eosinophil counts make the diagnosis of sarcoidosis unlikely [41,42,43]. Here, ITGAE is linked to sarcoidosis.