SOD1 and amyotrophic lateral sclerosis: The levels of glutathione peroxidase (GPx) activity, SOD, GR, malondialdehyde (MDA), and 8-OHdG were significantly increased in the serum of patients with ALS, with significantly increased levels of 8-OHdG, MDA, and glutathione, and decreased total antioxidant levels [26].