Whole-genome sequencing (WGS) of paired samples showed that the genomic structure of SMM is similar to symptomatic MM, and typical MM driver events are observed already at the SMM stage, i.e., t(4; 14), t(11; 14), del(1p), amp(1q21), or mutations in the NRAS and DIS3 genes [61]. This evidence concerns the gene DIS3 and Miyoshi myopathy.