Data from the largest population of patients with newly diagnosed MM sequenced (n = 1273) indicate that mutations in the most commonly mutated driver genes in MM, i.e., KRAS, NRAS, DIS3, FAM46C, and BRAF occur in 22, 17, 10, 9, and 8% of patients, respectively, while the frequency of mutations in other driver genes ranges from 0.3% to 5.5% [17]. Here, DIS3 is linked to Miyoshi myopathy.