Interleukin 8 (IL-8)—also known as CXCL8—is a chemokine produced in response to Aβ and proinflammatory stimuli, both in the CNS and the periphery [138,139], and has been found to be increased in the blood and CSF of AD patients [140,141]. The gene discussed is CXCL8; the disease is Alzheimer disease.