In this study, patients were either diagnosed with ALS or FLTD, a highly similar neurodegenerative disorder with several common hallmarks, or a combined diagnosis of ALS and FLTD and compared to a control group (detailed information on cohort selection size and composition, as well as used technique/antibody and detected TDP-43 levels can be found in Table 2). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.