TARDBP and amyotrophic lateral sclerosis: In addition, TDP-43 [31,32,33,34,35], a protein known to hyperphosphorylate and aggregate during ALS progression, and neurofilaments [28,29,36,40,41,42,43], the intermediate filaments of the nervous system that are known to contribute to ALS when failing to organise neuronal integrity, were found to be potentially relevant biomarkers.