In the described study, Feneberg et al. investigated combined CSF and serum samples, blood lymphocytes, brain material, and purified exosomes from CSF for TDP-43 by one- (1D), and two-dimensional (2D) Western immunoblotting (WB) and targeted mass spectrometry (multiple reaction monitoring (MRM)) in patients with ALS, FTLD and, non-neurodegenerative diseases [34]. Here, TARDBP is linked to amyotrophic lateral sclerosis.