NEFL and amyotrophic lateral sclerosis: One particular study we want to focus on in our review is a plasma and CSF combined study conducted by De Schaepdryver et al. The authors examined 85 ALS patients, 215 patients with various other neurological disorders (disease controls, DC), and 31 ALS mimics enlarging the so far conducted studies by a clear recommendation whether NfL and pNfH are able to distinguish between ALS and clinically highly similar disorders, such as Kennedy disease or motor neuropathy [43].