Human gene NR5A1 encodes steroidogenic factor 1, both a deficit and excess of which reduce human reproductive potential on the one hand via hyper-anxiety during impaired aggressive sexual behavior up to male infertility [77] as well as hypoestrogenism [78] leading to 1% of cases of female infertility [79], and on the other hand, hyperestrogenism elevates risks of endometriosis and others estrogen-dependent inflammatory disorders in women [80,81]. This evidence concerns the gene NR5A1 and hyperestrogenism.