Similarly, for murine embryos transferred at the two-cell stage between mice fed either a control or high-fat (HF) diet, both a pre-gestational and gestational HF diet resulted in fetal growth restriction and abnormal placentation [15] and, in the group in which embryos were transferred from HF to control dams, several imprinted genes, including IGF2 and IGF2R, which were differentially expressed in the placenta compared to when embryos were transferred between control dams [15]. The gene discussed is IGF2; the disease is hydrops fetalis.