PDGFRA and cancer: Among the genes that are most sensitive to acetyl-CoA abundance, Platelet Derived Growth Factor Receptor A (PDGFRA), a tyrosine kinase that is frequently dysregulated and promotes cell survival and metastasis in cancers [43,44,45], showed dramatic acetyl-CoA dependent changes in H3K27 acetylation around its transcriptional start site (TSS) [17].