Importantly, SIRT6 is implicated in tumor suppression by repressing transcription programs linked to cell proliferation, inflammation, ribosomal biogenesis, metabolic reprogramming, and genomic instability [27,32,33,34,35,36,37], and accordingly, down-regulated SIRT6 expression is observed in multiple human cancers [34,38]. This evidence concerns the gene SIRT6 and cancer.