SNCAIP and chronic kidney disease: In a large genome-wide association study on diabetic kidney disease, Salem et al. [20] were able to show that variant rs149641852 at chromosomal position 5:121774582 within SNCAIP is associated with extreme chronic kidney disease (defined as eGFR < 15 mL/min/1.73 m2), dialysis or renal transplant for the “CKD extreme” phenotype.