NF-κB-inducing kinase (NIK, also known as MAP3K14) signalling has been found to be essential in modulating the activity of the NF-κB pathway in pancreatic cancer [54], as the increased activity of the NF-κB pathway in pancreatic cancer caused cell proliferation and tumour development [55,56]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.