Here we report the occurrence of the MITF-E318K germline variant in 7/248 CM patients of a hospital-based cohort, which was screened for the germline status of CDKN2A and MC1R predisposition genes, and included multiple (n = 78), familiar (n = 74), sporadic (n = 59), patients diagnosed for melanoma and other tumors (n = 15), and pediatric cases (n = 22). Here, CDKN2A is linked to melanoma.