Besides its key role in signaling via Melanocortin-1 Receptor (MC1R) upon binding by α-Melanocyte Stimulating Hormone to induce melanin production, MITF governs the maintenance of melanocyte stem cells, cell cycle progression, differentiation, apoptosis, migration, DNA damage repair, chromosome stability and melanoma pathogenesis [1,2]. Here, MC1R is linked to melanoma.