Five out of 387 (1.3%) NPMc+ AML cases harbored rare NPM1 non-exon 12 mutations, specifically in exon 9 (n = 1), exon 11 (n = 1) and exon 5 (n = 3) [17] (Discrepancy 1, Figure 1). The gene discussed is NPM1; the disease is acute myeloid leukemia.