NPM1 and acute myeloid leukemia: In NPM1-mutated AML, this equilibrium is altered as the consequence of the gene mutation that occurs almost exclusively in the last exon of the gene (exon 12) causing changes at the C-terminus end of the protein, including loss of the NoLS and acquisition of a new NES, resulting in an aberrant dislocation of NPM1 in the cytoplasm of AML cells [1,13,14].