The overall risk of developing a potential VHL-related feature (haemangioblastoma, RCC or multiple renal cysts) was 17.3% at 10 years follow-up (Figure 2A), and the risk of developing a potential VHL-related tumour (haemangioblastoma or RCC) was 10.8% at 10 years follow-up (Figure 2B). This evidence concerns the gene VHL and Multiple renal cysts.