To dissect kinase-driven signaling events associated with the WT KRAS allele in mutant lung adenocarcinomas, we then captured, on a panel of 5 adenocaricnoma lines (A549, H1734, H23, H2122, H358), the expression and activation level of 183 signaling proteins by reverse-phase protein microarray (RPPA). This evidence concerns the gene KRAS and lung adenocarcinoma.