PACS2 and developmental and epileptic encephalopathy: Heterozygous mutations involving the PACS2 gene located on chr14:105,300,717-105,398,146 (OMIM #618067) cause developmental and epileptic encephalopathy-66 with facial dysmorphism and cerebellar dysgenesis, characterized by the onset of various types of seizures in the first days or weeks of life [65].