TERT and cancer: Additionally, this study also identified a subset of liver cancer samples that exhibit SCNAs resulting in duplication of the Telomerase reverse transcriptase (TERT) gene and enhancing its expression; TERT is a well known oncogene frequently duplicated in cancer and is responsible for extending telomeric DNA, thereby facilitating immortalisation of cancer cells by overcoming the Hayflick limit on the number of cell divisions [70,71,72,73,74].