TMPRSS2 and Familial prostate cancer: For instance, fusions of ETS transcription factor gene ERG with promoter elements of TMPRSS2 are observed in roughly 50% of prostate cancers (Figure 2C and Figure 3C), as well as MTOR-TP53BP1, SLC45A2-AMACR, and MAN2A1-FER fusions found at lower frequencies [89,129,131,155].