H3-4 and infection: An Arabidopsis mutant, wes1-D, in which a GH3 gene WES1/GH3.5 is activated by nearby insertion of the 35S enhancer, showed enhanced resistance to both biotic (pathogen infection) and abiotic stresses (including cold, heat, and drought stresses), and stress-responsive genes, such as pathogenesis-related genes and CBF genes, were up-regulated in this mutant [19].