While we failed to replicate our previous finding of decreased anxiety in Std-Pten+/− males [14], we did see a trend to a decrease in anxiety in EE-Pten+/+ females relative to Std-Pten+/+ females, and all groups showed a significant preference for thigmotaxis over center time (see Figure 4E–H, Supplemental Table S2). The gene discussed is PTEN; the disease is Anxiety.