AUTS2 and autism spectrum disorder due to AUTS2 deficiency: The large interindividual, and even intrafamilial, variability observed in patients with AUTS2 pathogenic variants led Beunders and colleagues in 2013 to establish what they called an AUTS2 syndrome severity score (ASSS), and that has been systematically used in the literature to assess the severity and phenotype of patients with AUTS2 syndrome [6].