We observed that CDK6-silenced Ph+ ALL cells are more susceptible to apoptosis and exhibit a slower disease progression in NSG mice than the palbociclib-treated counterparts, possibly as consequence of lower expression of genes involved in cell survival, chromatin remodeling and mitochondrial metabolic pathways for energy production observed in CDK6-silenced cells. This evidence concerns the gene CDK6 and acute lymphoblastic leukemia.