Hematological evaluation showed no anemia, but the child was diagnosed with hemoglobin E trait following identification of a known heterozygous pathogenic variant in HBB [(NM_000518.4 c.79G > A (p. Glu27Lys); (ClinVar: RCV000778330.1)], which explained the splenomegaly. Here, HBB is linked to anemia (phenotype).