EZH2 and pachyonychia congenita: We used public data from The Cancer Genome Atlas to create a map of association of key regulatory genes involved in proliferation activity, such as EZH2, MCM7, BRCA2, and c-MYC, in stressful pathway (BDNF and cortisol), and in inflammation microenvironment (CTLA4 and PD-L1) to test several multi-dimensional scaling models and create a combined gene-cluster to better predict PC.