Table 5 summarizes the number of assigned genes and the symbols of those captured both in the GWAS Catalog and by our EWAS. Notably, the genes ERICH1, ZNF595, SPAG1, and TP73 were contained in all sets as shown in Table 5. The genes HLA-DRB1 and HLA-DRB5, well-known to be associated with RA risk, were identified in both the GWAS set and ACPA-DMR set. Here, SPAG1 is linked to rheumatoid arthritis.