Figure 6 shows results of random permutation analyses to answer this question, for ACPA-associated DMCs, ACPA-associated gDMCs and RA-associated DMCs, respectively. Similar to Figure 3, the three plots in the first row compare the null distribution of the number of overlapping CpGs obtained from random permutations with the observed number of overlaps. Here, PRTN3 is linked to rheumatoid arthritis.