HK1 and hepatocellular carcinoma: It has been reported that the silencing of SDHB in hepatocellular carcinoma cell lines leads to an alteration in energy metabolism and an almost complete loss of mitochondrial membrane potential, as well as a decrease in the expression of Complex III and IV of oxidative phosphorylation, causing an increase in the acidity of the medium, an increase in glucose uptake, and an overexpression of hexokinase 1 (HK1) [48], which is in agreement with the HK1 overexpression found in the present work.