For the ACACA gene, an overexpression of 6 to 153-fold was found in CNS WHO grade 1 and 2 gliomas, while the expression levels of CNS WHO grade 3 and 4 gliomas showed 1534 to 5133-fold increases with respect to HMC3 (Figure 3D). The gene discussed is ACACA; the disease is central nervous system cancer.