Results indicate that GA-II with or without recurrent vomiting, encephalopathy, metabolic acidosis, and hypoglycemia is linked significantly with likely pathogenic variants such as ETFDH:p.Gln269His, ETFDH:p.Ser442Leu, ETFDH:p.Gly472Arg, and ETF:p.Ile346Phefs*19. Here, ETFDH is linked to Encephalopathy.