HNF1A and endothelial dysfunction: Interestingly, a recent study exploring the consequences of HNF1A splicing in human endothelial cells derived from induced pluripotent stem cells found that compared with the control, the endothelial cells with aberrant HNF1A transcripts showed increased vascular permeability and expression of ICAM-1 in response to pro-inflammatory cytokine TNFα, contributing to endothelial dysfunction.