Of the 14 downregulated genes, 8 genes (TRPC3, ITPR1, CACNA1A, CACNA1D, P2RX7, ATP2B3, ATP2B4, and ASIC2) showed a similar pattern with lower expression levels in GTML tumour tissues, while ORAI3 was the only gene that showed an opposite pattern with higher expression in GTML tumour tissues compared to the control mice tissues (Figure 5). The gene discussed is CACNA1D; the disease is neoplasm.