This list included TP53, APC, PTEN, EGFR, VHL, PDE4DIP, CDKN2A, TET2, PIK3CA, KIT, etc. Similarly, the list when sorted out on the “fraction of mutations in clusters” contained important oncogenes in leukemia CTNNB1, CEBPA, SOCS1, NRAS, IDH1, NPM1, PPP2R1A, PTPRT, MYD88, and IDH2. This evidence concerns the gene PIK3CA and leukemia.