Upregulated expression of SLC7A11 (10/14), SLC1A5 (7/14), SLC7A5 (6/14), and SLC3A2 (5/14) was observed in most of the tumor tissues; however, GLS in LUSC, KIRC, and KICH and GLS2 in KIRC and LIHC, were significantly downregulated. The gene discussed is SLC7A11; the disease is neoplasm.