For example, yeast has been successfully used to examine the relationship between the ZMPSTE24 enzyme and Laminin A substrate involved in Hutchinson–Gilford progeria syndrome (HGPS) [91,92] or to investigate how the interaction ligand/receptor can be improved for a more efficacious therapy, as conducted for IL-10 and IL-10Rβ receptors by yeast surface display engineering platforms [93]. The gene discussed is ZMPSTE24; the disease is Hutchinson-Gilford progeria syndrome.