The ZEB proteins are part of a group of transcription factors (including Snail, Slug, KLF8 and others) that regulate this process, and while they have been shown to be specifically involved with cell plasticity, for instance through their ability to repress the adhesion molecule E-cadherin, they contribute to several other cellular events that promote cancer, such as enhancing cell cycling and acquisition of drug resistance [64]. The gene discussed is KLF8; the disease is cancer.