Parallel to the well characterized interaction between the Let-7 microRNA family and SALL4 during development, several recent studies demonstrate that Let-7/miR-98 may act as a tumor suppressor via targeting SALL4 in HCC, non-small cell lung cancer (NSCLC), and ovarian carcinoma [14,15,16]. Here, SALL4 is linked to hepatocellular carcinoma.